This course provides an overview of state-of-the-art prescriptive analytics to approach business challenges in the digital era. Participants learn how to analyze processes, identify crucial tradeoffs and make value-enhancing decisions. Selected topics include bottleneck analysis, queueing models, dynamics of supply chain management, and managing variability in supply chains. Participants will also get familiar with concepts, concerns, developments, and trends in environmentally and socially responsible supply chains, and learn what can be done to mitigate the sustainability impacts in supply chains.